In 1998, American scientists Andrew Fire and Craig Mello published a groundbreaking paper in Nature, confirming that double-stranded RNA (dsRNA) is the cause of post-transcriptional gene silencing (PTGS) in nematodes. They call this phenomenon RNA interference (RNAi).   The discovery of RNAi (Fig. 1) explains the confusing gene silencing… Continue Reading The world’s first RNAi drug “born” for 20 years and will “explode” in the next 10 years.

  In 2006, Stanford University professor Andrew Z. Fire and University of Massachusetts Medical Professor Craigc. Mello won the 2006 Nobel Prize in Physiology/Medical for discovering RNA interference (RNAi) and their outstanding contributions in the field of gene silencing. At the time of the award, they predicted that the application… Continue Reading 2018 Top Ten RNA Therapy Company, the first place is not Moderna?

Since RNAi (RNA interference) was first discovered 20 years ago, researchers from both academic institutions and pharmaceutical companies have been hoping to develop this technology into new therapies that can treat diseases, but so far there is no one. Related drugs are listed.   Fortunately, however, Alnylam Pharmaceuticals, a pioneer… Continue Reading After 20 years of agitation of RNAi drugs, hope is in sight.