From the discovery of tubulin to the approval of vinblastine for anticancer treatment, it has been more than half a century. Microtubules play an extremely important role in cell division, and disruption of the formation of mitotic spindles affects all dividing cells. For cancer cells that proliferate faster than… Continue Reading The development of microtubule inhibitors – the big story of small molecules
The prototype of the best-selling book “The Billion-Dollar Molecule” in the pharmaceutical industry is Vertex. The company, which was founded in 1989, started with $10 million in funds and can be said to be a dark horse enterprise in the pharmaceutical industry. Vertex has created three drugs with annual… Continue Reading “The Billion-Dollar Molecule” prototype Vertex’s “Next City”
Many people are troubled by stomach problems for many years, so what is the reason? Bad habits and mental stress were once considered to be major factors, but there is another reason that must be mentioned, that is, Helicobacter pylori. I. Discovery of Helicobacter pylori In 1982, Australian… Continue Reading Do you know about Helicobacter pylori?
Gump’s troubles In 2013, Gump’s actor, the second American movie star Tom Hanks, who won the Oscar for Best Actor Award for two consecutive years, frankly told the hosts and viewers on a nighttime talk show: “When I went to see a doctor, he said to me, ‘Do you… Continue Reading From lizard venom to a new drug for type 2 diabetes – Lyxumia
The human fertilization process is usually described as a massive swimming marathon, and only the fastest and strongest sperm can win the reward of combining with the egg cells. However, the real process of human fertilization is very different from what people imagine. In this article, the famous biological… Continue Reading The fastest and strongest sperm can be combined with the egg? In fact, it’s luck.
There is an uncle, 50 years old, slightly fat, hyperuricemia for more than 10 years, blood uric acid highest 620μmol / L, the lowest after diet control is 540μmol / L. He usually does not need medicine, and he uses a painkiller when there is a gout attack. A… Continue Reading Why are so many people unable to get rid of gout?
The original research pricing strategy caused controversy A few years ago, a group of oncologists wrote an editorial on drug prices, with the breakthrough tyrosine kinase inhibitor Gleevec (imatinib mesylate) as an example of extreme pricing practices. This has sparked a major discussion about the price and value of… Continue Reading Reflection on Gleevec pricing
Seeing life and death, people will become numb, probably people will always have such misunderstandings about doctors. But no one will be more excited than them when revolutionary therapies emerge. Sixty-three children with B-cell acute lymphoblastic leukemia who have no other treatment options have a very low chance… Continue Reading The next step of CAR-T therapies
Trabexidine In the late 1980s, Brian Bingham was still a Ph.D. He carries his bags to the Florida Keys every month. Among the mangroves that surround the island, there is the sea squirts that the marine biologist has been studying, and it is also the best place to study… Continue Reading Trabexidine: the first anti-tumor drug derived from the ocean
One day in 2010, Bruce Levine and Carl June, two immunologists at the University of Pennsylvania, were anxiously awaiting confirmation of the treatment outcomes of several patients. They are conducting a clinical trial of a new type of anti-tumor therapy in which three leukemia patients who have no medically available… Continue Reading Twenty years of CAR-T therapy and the glory days of Bruce Levine