From chicken embryo stem cells to snake-tooth-shaped microneedle patches, here are some stunning pictures selected from the annual photos of The Scientist Magazine 2019, let’s experience the beauty of science and art together. 1. Trajectory of chicken embryonic stem cells during development Within 16 hours, the location of… Continue Reading Photo Picks of the Year 2019, A Combination of Science and Art
Cancer is one of the leading causes of death worldwide, and distant metastases cause more than 90% of cancer deaths. Due to the limited resolution of imaging technologies such as bioluminescence and MRI, scientists have not been able to comprehensively detect metastatic cells throughout the body, which has greatly… Continue Reading Cell releases blockbuster black technology: fully revealing cancer metastasis
Figure ①: Antitumor biology of γδ T cells Figure 1 illustrates the antitumor function of γδ T cells and its regulatory mechanism. γδ T cells directly recognize tumor cells through T cell receptors (TCR) and natural killer cell receptors (NKRs), and regulate tumor cell killing through a variety of… Continue Reading Cancer immunotherapy 12 pictures
Pharmacophore There must be a specific binding site in the drug-forming target that binds to the drug. Compounds that are active against a target must have similar structural features. The most common shared property of these compounds is defined as pharmacophores. The significance of the pharmacophore model The… Continue Reading RDKit: Visual Pharmacophore
Alzheimer’s disease, commonly known as Alzheimer’s disease, is a neurodegenerative disease. Patients may experience memory loss, language problems, slow response, lost, mental behavior, etc., and even worse, they will not know their loved ones. According to the data, 50 million people in the world suffer from Alzheimer’s disease in… Continue Reading Is the vaccine returning to the development of new drug development for Alzheimer’s disease?
In order to support its uncontrolled growth, tumors devour large amounts of nutrients. For decades, scientists have been trying to develop drugs that cut off the “food” supply of tumors. On November 7, a recent study published in the journal Science, the team from the Johns Hopkins Cancer… Continue Reading Science: Greatly improve the efficacy of PD-1, new anticancer drugs will start human trial next year
Mutations in the oncoprotein KRAS occur in about 25% of cancer cases and are associated with poor prognosis of the disease. Therefore, scientists believe that blocking KRAS signaling is a potential anti-cancer pathway. However, previous decades of research have shown that this protein may be a “non-medicinal” target because… Continue Reading Nature: KRAS drugs enter the “outbreak period”, 5 products carry out human trials
On November 7, Arkuda Therapeutics announced the completion of a $44 million Series A round of financing, led by Atlas Venture and Pfizer Ventures, and Tekla Capital Management and BioInnovation Capital. The company will use the funds to promote its treatment of frontotemporal dementia (FTD) drugs through Phase I… Continue Reading Targeting granule protein precursors to prevent dementia, this company is spotlighted by Pfizer
I. Introduction Histamine was first discovered in the last century. It is the main medium for many biological reactions including allergic reactions. Some of these biological reactions are involved in the pathophysiological processes of common skin diseases. In theory, there are three ways to block the biological effects… Continue Reading Antihistamines for itch treatment
Immunotherapy is considered to be the fourth pillar of cancer treatment (in parallel with surgery, radiotherapy, and chemotherapy), by enhancing the ability of the immune system to target and kill tumor cells, including: 1) Blocking antibodies to the inhibitory immune checkpoint pathway 2) Cell therapy based on dendritic cells… Continue Reading Nature: The next step in cancer immunotherapy is joint therapy. Eradication of cancer is not the ultimate goal.