In 1998, American scientists Andrew Fire and Craig Mello published a groundbreaking paper in Nature, confirming that double-stranded RNA (dsRNA) is the cause of post-transcriptional gene silencing (PTGS) in nematodes. They call this phenomenon RNA interference (RNAi). The discovery of RNAi (Fig. 1) explains the confusing gene silencing… Continue Reading The world’s first RNAi drug “born” for 20 years and will “explode” in the next 10 years.
Drug: metformin Magazine: Nature and its publications Highlights: 1) Metformin + heme inhibits tumor growth in triple negative breast cancer 2) Metformin + BCL-2 inhibitor + PD-1 antibody can significantly prolong the survival of breast cancer mice Metformin was discovered in 1922 and began clinical application in 1957.… Continue Reading Metformin combined treatment of breast cancer is expected
Drug: NKG2A antibody Magazine: Cell & Nature Highlights: Cancer immunotherapy has a new target – NKG2A, I / II clinical trial data “giving expectations”, but the future is still unclear In recent years, cancer immunotherapy has achieved unprecedented success, but only a few patients have shown lasting efficacy. Improving… Continue Reading A new target for cancer immunotherapy – NKG2A, the future is unknown
On March 4, Novartis published a clinical trial of a Phase III study of Cosentyx in the treatment of moderate to severe plaque psoriasis at the 2019 Annual Meeting of the American Academy of Dermatology (AAD2019). The reason for this study is that 441 of the 543 patients with… Continue Reading The third phase of clinical data of Cosynmyx China, a new psoriasis drug, was released for the first time: excellent efficacy and significant benefit
A female patient, 53 years old, found “rheumatoid arthritis” for 14 years. She was treated with “painkiller” for a long time. She had chronic stomach and enteritis a few years ago and her diet has been bad. Recently, the body was extremely weak and struggling to walk. The family… Continue Reading Long-term use of painkillers, the consequences may be more serious than you think
On February 27th, Bayer announced its 2018 financial report. The Group achieved a total revenue of 39.586 billion euros, an increase of 13.1% compared with 2017. The total revenue of the pharmaceutical business was 16.746 billion euros (-0.6%), the income from consumer health business was 5.45 billion euros (-7%),… Continue Reading Bayer 2018 earnings report: Acarbose reverse growth! New drug development is broken, the structure is about to be adjusted
Drug: CAR-T therapy Magazine: Nature Highlights: A clever design that increases the anti-cancer ability of CAR-T therapy More and more cancer patients are being treated with CAR-T cell therapy. CAR, the English full name of Chimeric Antigen Receptor, chimeric antigen receptor, is a kind of “navigation” that… Continue Reading Upgraded version of CAR-T therapy, greatly improved anti-cancer ability
Human immunodeficiency virus (HIV) is a retrovirus that infects cells of the human immune system, destroying or damaging its function. There is no symptom at the beginning of HIV infection, but as the infection progresses, the immune system begins to weaken. The final stage of infection is the acquired… Continue Reading Can immunotherapy create a miracle to cure AIDS?
In November last year, the Financial Times discussed some of the characteristics of the transformation of the Chinese pharmaceutical industry at the “2018 Pharmaceutical & Biotechnology Summit” held in London. At the meeting, the host threw out a poll of “When do you think China might become an important… Continue Reading The new road of Chinese pharmaceutical companies
Drug: maraviroc Magazine: Cell Highlights: 1) First confirmed that CCR5 gene is associated with stroke rehabilitation 2) HIV drug maraviroc can promote recovery of mice from stroke 3) First reported the function of CCR5 in the human brain Stroke is an acute cerebrovascular disease caused by sudden rupture… Continue Reading Are HIV drugs used for “stroke rehabilitation”? Cell first confirmed that the genes edited by He Jiankui affect the human brain