From chicken embryo stem cells to snake-tooth-shaped microneedle patches, here are some stunning pictures selected from the annual photos of The Scientist Magazine 2019, let’s experience the beauty of science and art together. 1. Trajectory of chicken embryonic stem cells during development Within 16 hours, the location of… Continue Reading Photo Picks of the Year 2019, A Combination of Science and Art
Cancer is one of the leading causes of death worldwide, and distant metastases cause more than 90% of cancer deaths. Due to the limited resolution of imaging technologies such as bioluminescence and MRI, scientists have not been able to comprehensively detect metastatic cells throughout the body, which has greatly… Continue Reading Cell releases blockbuster black technology: fully revealing cancer metastasis
Figure ①: Antitumor biology of γδ T cells Figure 1 illustrates the antitumor function of γδ T cells and its regulatory mechanism. γδ T cells directly recognize tumor cells through T cell receptors (TCR) and natural killer cell receptors (NKRs), and regulate tumor cell killing through a variety of… Continue Reading Cancer immunotherapy 12 pictures
Pharmacophore There must be a specific binding site in the drug-forming target that binds to the drug. Compounds that are active against a target must have similar structural features. The most common shared property of these compounds is defined as pharmacophores. The significance of the pharmacophore model The… Continue Reading RDKit: Visual Pharmacophore
Alzheimer’s disease, commonly known as Alzheimer’s disease, is a neurodegenerative disease. Patients may experience memory loss, language problems, slow response, lost, mental behavior, etc., and even worse, they will not know their loved ones. According to the data, 50 million people in the world suffer from Alzheimer’s disease in… Continue Reading Is the vaccine returning to the development of new drug development for Alzheimer’s disease?
In order to support its uncontrolled growth, tumors devour large amounts of nutrients. For decades, scientists have been trying to develop drugs that cut off the “food” supply of tumors. On November 7, a recent study published in the journal Science, the team from the Johns Hopkins Cancer… Continue Reading Science: Greatly improve the efficacy of PD-1, new anticancer drugs will start human trial next year
Mutations in the oncoprotein KRAS occur in about 25% of cancer cases and are associated with poor prognosis of the disease. Therefore, scientists believe that blocking KRAS signaling is a potential anti-cancer pathway. However, previous decades of research have shown that this protein may be a “non-medicinal” target because… Continue Reading Nature: KRAS drugs enter the “outbreak period”, 5 products carry out human trials
On November 7, Arkuda Therapeutics announced the completion of a $44 million Series A round of financing, led by Atlas Venture and Pfizer Ventures, and Tekla Capital Management and BioInnovation Capital. The company will use the funds to promote its treatment of frontotemporal dementia (FTD) drugs through Phase I… Continue Reading Targeting granule protein precursors to prevent dementia, this company is spotlighted by Pfizer
Prostate cancer is a male androgen-dependent tumor. Androgen stimulates the growth of prostate cancer cells and induces disease progression. Metastatic prostatectomy (ADT) is commonly used in patients with metastatic prostate cancer. The initial response rate can reach 80%-90%, but almost all patients will eventually progress to metastatic castration-resistant prostate… Continue Reading Competition pattern of new drug development in advanced prostate cancer
Chronic atrophic gastritis (CAG) refers to the localization of the gastric mucosa, extensive glandular reduction, atrophy and thinning of the mucosa. Chronic atrophic gastritis has no specific symptoms, high recurrence rate, and is associated with certain gastric cancer risk and is not easy to cure. How to treat chronic… Continue Reading How to treat chronic atrophic gastritis?