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Strictly speaking, as long as you take the medicine, you are no longer suitable for drinking. Whether it is red wine beer or white wine. Not only cephalosporins, but also a few major types of drugs are particularly deadly to alcohol. Taking these drugs and drinking them will lead to a series of medical dissatisfaction called disulfiram reaction, which is life-threatening.


What is the disulfiram reaction?

The reaction caused by drinking after taking medicine is called disulfiram reaction. Disulfiram itself is a drug for alcohol withdrawal. When used in combination with ethanol, disulfiram can inhibit acetaldehyde dehydrogenase in the liver. After the oxidation of ethanol to acetaldehyde in the body, it can no longer decompose and oxidize, resulting in B. The aldehyde accumulates to produce a series of reactions.

Many drugs have a similar effect to disulfiram. If you drink alcohol after treatment, facial flushing, conjunctival hyperemia, blurred vision, severe pulsation of head and neck blood vessels or pulsating headache, dizziness, nausea, vomiting, sweating, dry mouth, chest pain, myocardial infarction, acute heart failure, dyspnea, acute liver injury, convulsions and death.


The first category: cephalosporin antibiotics (including cefoperazone, cefoperazone sulbactam, ceftriaxone, cefazolin, cefradine, cefmetazole, cefminox, cephalosporin, cefmenoxime, Cefmendo, cephalexin, cefaclor, etc., furazolidone tablets, chloramphenicol, nitrofurantoin, metronidazole, etc.

Cephalosporin + wine = poison

After eating cephalosporin drugs or cephalosporin anti-inflammatory needles, and then drinking, there will be a “disulfiram-like reaction”!

So what is it? It is also known as the alcohol-free sulfur-like reaction, mainly because of the consumption of alcohol after oral administration of cephalosporins, resulting in a toxic reaction caused by acetaldehyde accumulation in the body. Mainly manifested as chest tightness, shortness of breath, laryngeal edema, lip purpura, difficulty breathing, increased heart rate, decreased blood pressure, hallucinations, paralysis, and even anaphylactic shock.

In addition, the severity of the disulfiram-like reaction is proportional to the dose of the drug and the amount of alcohol consumed. Drinking liquor is more reactive than beer and alcoholic beverages. Drinking during the period of drinking is more important than drinking after stopping the drug. People who have a cardiovascular underlying disease may be severely responsible for respiratory depression, heart failure and even death.

So, how long is it safe to drink and take medicine?

A survey analysis showed that people who were exposed to cephalosporin antibiotics within 5 days of drinking may have a disulfiram-like reaction. After 6 days of drinking, taking the medicine is safe.


The second category: sedative hypnotic drugs

Sleeping pills + wine = one life

Brain inhibitors such as phenobarbital, chloral hydrate, diazepam, and chlordiazepoxide are accelerated by the body under the action of ethanol, and at the same time slow down their metabolism, so that the concentration of the drug component in the blood is Rapidly increased in the short term.

After drinking alcohol, alcohol is excited and inhibited by the central nervous system. Together with these brain inhibitors, the normal activities of the central nervous system are severely inhibited, which can lead to coma, shock, respiratory failure, and death.

It is said that the comedy master Chaplin died of drinking hypnotics after drinking.

Sleeping pills (estazolam or zolpidem) can cause dangerous consequences if combined with alcohol, because alcohol can aggravate the calming effect of sleeping pills and inhibit brain activity, causing severe sleepiness and dizziness. If the user is active, it increases the risk of falls, injuries and accidents.

Drinking hypnotics while drinking large amounts of alcohol can lower blood pressure to extremely low levels and cause difficulty breathing.


The third category: antipyretic analgesics

Painkiller + wine = gastrointestinal bleeding

Such as aspirin, paracetamol and so on. These drugs have stimulating and damaging effects on the gastric mucosa, and alcohol also afflicts the stomach. Both of them can cause gastritis, gastric ulcer, and stomach bleeding.


The fourth category: reserpine, anticancer agents, “isoniazid” (anti-tuberculosis drugs) and other drugs

Antihypertensive drug + alcohol = hypotension shock

There are many kinds of wines, and if you drink wine after taking these medicines, it is easy to have an accident.

Friends taking antihypertensive drugs, including reserpine, captopril, nifedipine, antihypertensive drugs, if drinking alcohol, may cause vasodilation, hypotension, even shock, life-threatening.

Because of the tyramine contained in wine, if it is accumulated in a large amount, it will cause significant harm to the human body, leading to dizziness, headache, nausea and vomiting, diarrhea, arrhythmia, elevated blood pressure and even cerebral hemorrhage.

When drinking normally, the tyramine can be naturally destroyed by the human body. However, if the drug is not successfully destroyed by the human body after taking such a drug, it is inevitable that the accident will be easy, and the consequences are quite serious.


The fifth category: hypoglycemic drugs

Hypoglycemic agents + alcohol = hypoglycemia shock

People with diabetes should pay special attention. During the injection of insulin or oral hypoglycemic drugs, if they drink on an empty stomach, they may be prone to hypoglycemia.

Alcohol stimulates insulin secretion, and if the patient has just taken the hypoglycemic agent, the blood sugar has dropped to the standard value. At this time, alcohol causes insulin to increase secretion, which is bound to cause hypoglycemia. Especially after taking glibenclamide or drinking alcohol after injecting insulin, the chance of hypoglycemia is higher.

In addition, hypoglycemic agents such as metformin may have a rare but very serious side effect if mixed with alcohol – it increases the risk of lactic acidosis, which is the accumulation of lactic acid in the blood, causing nausea, weakness, etc. symptom.

Furthermore, long-term drinking can increase the probability of ketosis while causing liver damage. Because alcohol can fight the body’s insulin, inhibiting the liver’s sugar metabolism. Therefore, if people with diabetes drink a lot, it may induce ketosis.

It is worth noting that this symptom of hypoglycemia is manifested as palpitation, sweating, fatigue, and even irritability, confusion, and multilingualism. These symptoms are often masked by drunken reactions and are not easily distinguished from drunkenness. This has led to the appearance of hypoglycemic shock in the event of severe and persistent hypoglycemia.

If left untreated, it may cause irreversible damage to the brain tissue and even cause death.


Category 6: Antidepressants

Antidepressant + wine = aggravating condition, rising blood pressure

Antidepressants and alcohol consumption can delay the running rhythm of the central nervous system, affecting the function and thinking ability of the brain, and weakening the alertness. The combination of the two can make people feel sleepy, reduce people’s ability to judge, body coordination and reaction time, and even lead to the deterioration of symptoms of depression.

For people with depression who take monoamine oxidase inhibitors, alcohol also interacts with these drugs, causing blood pressure to rise, which is dangerous, so doctors recommend that such patients avoid alcohol completely.

For people with depression who take selective serotonin reuptake inhibitors (such as sertraline, fluoxetine hydrochloride, and paroxetine), although there is not enough evidence to prove that the drug will react adversely with alcohol, it is due to alcohol. It can cause dizziness, lethargy, and inattention, so it is recommended that you do not drink alcohol.


Category 7: Treatment of arthritis drugs

Treatment of arthritis drugs + wine = stomach ulcers, liver damage

Such as celecoxib capsules, naproxen, diclofenac sodium and the like. When the above drugs are mixed with alcohol, they may cause side effects such as ulcers, stomach bleeding, and liver damage. With celecoxib capsules, you can’t drink alcohol, especially if the drug has a higher risk of cardiovascular side effects, such as heart attacks and strokes, and alcohol increases this risk.

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