On March 25, AstraZeneca announced that the European Medicines Agency (EMA) officially approved its SGLT-2 inhibitor, Forxiga (Dalagide) as adjunctive therapy for insulin, for optimal use of optimal doses of insulin to control poor blood sugar. Type 1 diabetes patients (BMI ≥ 27). This is the first time that… Continue Reading SGLT-2 inhibitors first approved for the treatment of type 1 diabetes
“Big Pharmaceuticals” has been committed to producing a wide range of innovative drugs for many years. For them, gene therapy may be the place to give birth to the next “miracle.” Gene therapy, as its name implies, is a treatment that replaces defective genes with normal genes and has… Continue Reading Gene therapy is the leader, attracting countless giants to compete!
On March 7, the New England Journal of Medicine published the results of a Phase I study of BI 655139 in the treatment of generalised pustular psoriasis (GPP). Pustular psoriasis is a rare type of psoriasis, accounting for no more than 1%. It is usually divided into generalized pustular… Continue Reading Boehringer Ingelheim first in class monoclonal antibody is surprisingly effective for rare psoriasis
In 1998, American scientists Andrew Fire and Craig Mello published a groundbreaking paper in Nature, confirming that double-stranded RNA (dsRNA) is the cause of post-transcriptional gene silencing (PTGS) in nematodes. They call this phenomenon RNA interference (RNAi). The discovery of RNAi (Fig. 1) explains the confusing gene silencing… Continue Reading The world’s first RNAi drug “born” for 20 years and will “explode” in the next 10 years.
Drug: metformin Magazine: Nature and its publications Highlights: 1) Metformin + heme inhibits tumor growth in triple negative breast cancer 2) Metformin + BCL-2 inhibitor + PD-1 antibody can significantly prolong the survival of breast cancer mice Metformin was discovered in 1922 and began clinical application in 1957.… Continue Reading Metformin combined treatment of breast cancer is expected
Drug: NKG2A antibody Magazine: Cell & Nature Highlights: Cancer immunotherapy has a new target – NKG2A, I / II clinical trial data “giving expectations”, but the future is still unclear In recent years, cancer immunotherapy has achieved unprecedented success, but only a few patients have shown lasting efficacy. Improving… Continue Reading A new target for cancer immunotherapy – NKG2A, the future is unknown
On March 4, Novartis published a clinical trial of a Phase III study of Cosentyx in the treatment of moderate to severe plaque psoriasis at the 2019 Annual Meeting of the American Academy of Dermatology (AAD2019). The reason for this study is that 441 of the 543 patients with… Continue Reading The third phase of clinical data of Cosynmyx China, a new psoriasis drug, was released for the first time: excellent efficacy and significant benefit
A female patient, 53 years old, found “rheumatoid arthritis” for 14 years. She was treated with “painkiller” for a long time. She had chronic stomach and enteritis a few years ago and her diet has been bad. Recently, the body was extremely weak and struggling to walk. The family… Continue Reading Long-term use of painkillers, the consequences may be more serious than you think
On February 27th, Bayer announced its 2018 financial report. The Group achieved a total revenue of 39.586 billion euros, an increase of 13.1% compared with 2017. The total revenue of the pharmaceutical business was 16.746 billion euros (-0.6%), the income from consumer health business was 5.45 billion euros (-7%),… Continue Reading Bayer 2018 earnings report: Acarbose reverse growth! New drug development is broken, the structure is about to be adjusted
Drug: CAR-T therapy Magazine: Nature Highlights: A clever design that increases the anti-cancer ability of CAR-T therapy More and more cancer patients are being treated with CAR-T cell therapy. CAR, the English full name of Chimeric Antigen Receptor, chimeric antigen receptor, is a kind of “navigation” that… Continue Reading Upgraded version of CAR-T therapy, greatly improved anti-cancer ability