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The patient, male, 36 years old, developed sore throat after a cold, fever in a local hospital, diagnosed with upper respiratory tract infection, and received levofloxacin. After intravenous infusion of 0.2 g of levofloxacin, there was chills, chills, low back pain, yellow staining of the skin sclera, and then the wine was discharged. Upon examination, he had “Favism”, and the patient’s own and his son’s glucose-6-phosphate dehydrogenase (G-6-PD) activity decreased slightly.

 

I. What is Favism?

Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is due to defects in G-6-PD on the erythrocyte membrane, which reduces the production of reduced glutathione that maintains erythrocyte membrane stability, but not A genetic disease that resists oxidative damage and ultimately leads to destruction of red blood cells and hemolysis. Patients often develop symptoms due to the consumption of broad beans, commonly known as “Favism.”

Favism, a hereditary disease, has a male to female prevalence of about 7:1.

II. Which drugs can induce Favism?

Most patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency have no clinical symptoms for life, and usually do not affect life expectancy and quality of life in the absence of disease. Partially severe patients can cause severe hyperbilirubinemia in the neonatal period, or non-immune hemolysis induced by infection, food or drugs, and life-threatening.

After using the drug, if you have symptoms such as general malaise, fatigue, fever, chills, pale, jaundice, low back pain, urine brown or dark red within a few hours or days, you should seek medical attention immediately!

III. How to prevent Favism?

 

1. Use Chinese medicine carefully

It has been confirmed that berberine hydrochloride can induce “Favism”. Chinese herbal medicines such as berberine, Phellodendron, celandine, horsetail lotus, three needles, and top ten credits all contain berberine. Therefore, patients with Favism should try to avoid using proprietary Chinese medicines containing these herbs.

 

2. Avoid using compound cold medicine

Compound cold medicine usually contains acetaminophen, aspirin, and chlorpheniramine, all of which can induce Favism. Therefore, patients with Favism should avoid the use of compound cold medicine.

Ibuprofen can be used when antipyretic analgesics are used.

 

3. Fasting broad beans and products

Anyone who has suffered from this disease or who has suffered from this disease in their family, whether adults or children, should be prohibited from eating raw and cooked broad beans and stay away from broad bean pollen.

Breastfeeding after the mother eats broad beans may cause the baby to develop. Therefore, during lactation, it is best not to eat raw and cooked broad beans during breastfeeding to prevent the baby from getting sick through breast milk.

 

4. Away from mothballs

Clothing that uses mothballs to deworm can cause hemolytic reactions in children through contact, so try not to wear clothing stored with mothballs.

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