Illumination accelerates the oxidation of drugs. Some chemically unstable drugs decompose after exposure to light, which not only reduces the activity of the drug, but also seriously affects the efficacy of the drug. It also increases the toxicity of the drug, causing severe and even life-threatening.
Clinically, many drugs need intravenous infusion. How many do you know?
1. Sodium nitroprusside for injection
When infusion, the infusion set must be wrapped with aluminum foil or opaque material to protect it from light. This product is sensitive to light, poor solution stability, accelerated decomposition under light, sodium nitroprusside after light irradiation, the formation of excited sodium nitroprusside. It then breaks down into hydrated potassium ferricyanide and nitrogen oxides. Further decomposition of hydrated potassium ferricyanide produces toxic hydrocyanic acid and Prussian blue. Therefore, the injection should be prepared immediately before use, avoid light drip, and run out within 12h. If it turns dark brown, orange or blue, it should be discarded.
2. Itraconazole injection
Only dilute with 50 ml of 0.9% saline for injection provided with the package. The mixed solution should be used immediately and avoid direct light. It can be administered under normal room lighting.
3. Micafungin sodium for injection
Since this product can slowly decompose under the light, direct sunlight should be avoided. If it takes more than six hours from the preparation to the end of infusion, the infusion bag should be shading. (It is not necessary to block the infusion tube.) Do not shake the infusion bag vigorously when dissolving the product. This product is easy to foam and the foam does not disappear easily.
4. Nitroglycerin injection
Use light-proof measures when using this product intravenously. Intravenous instillation of this product, because many plastic infusion devices can absorb nitroglycerin, so should use non-adsorbed infusion device.
5. Nimodipine injection
Under diffuse sunlight or artificial light, no special protective measures are required within 10 hours of using this product; if inevitably exposed to sunlight during infusion, black, brown or red glass syringes and infusion tubes should be used or not used. The light-transmitting material wraps the infusion pump and the infusion tube. The active ingredient of nimodipine infusion is slightly light sensitive and should be avoided when used in direct sunlight.
6. Lipoic acid injection
With a good infusion, wrapped with aluminum platinum paper to protect light, can be stable within 6 hours. This product cannot be used in combination with glucose solution, Ringer’s solution and all solutions that may react with sulphur groups or disulfide bonds.
7. Fleroxacin Injection
Avoid slow light intravenous drip. It cannot be used in the same infusion tube as polyvalent metal ions such as Ca2 and Mg2. This product can cause photosensitivity reaction, at least 12 hours after the light is acceptable for treatment, during treatment and within a few days after treatment should avoid prolonged exposure to bright light. This product is unstable to light, prone to photolysis reaction, so that the antibacterial activity decreased. The photoexcited reaction is an exothermic reaction and is more likely to occur under solution conditions and aerobic conditions.
8. Enoxacin for injection
This product is dissolved in 100ml of 5% glucose injection every 0.2g, and it is infused intravenously. Photosensitivity may occur when using fluoroquinolones. When using this product, excessive exposure to sunlight should be avoided. If photosensitized reaction occurs, it should be stopped.
9. Mecobalamin Injection
Easy to decompose under light, use immediately after opening, should pay attention to avoid light.
10. Water-soluble vitamins for injection
When adding glucose injections for infusion, care should be taken to avoid light.
11. Coenzyme Q10 Sodium Chloride Injection
This product is easy to break down. Intravenous infusion, please complete the infusion within 2 hours; prolonged infusion should be taken to avoid light. This product may appear mist crystal, should be carefully examined before use, if crystal, heat in boiling water for 10-15 minutes, remove, shake, put to room temperature clarification, you can use.
12. Epirubicin hydrochloride
This product should be protected from light during preservation and administration. According to recent reports from abroad, fractional administration or dark spots can significantly reduce adverse reactions. Protective gloves should be worn on contact with the drug. Once the skin or mucous membrane comes into contact with the drug’s powder or solution, rinse with soap or water. The eye conjunctiva is flushed with saline.
13. Cisplatin for Injection
Avoid light during intravenous infusion.
14. Fat emulsion injection
As a preventive measure, it is recommended that during the phototherapy of newborns, infusion of fat emulsion should be protected from light. There are data showing that in light therapy, fat emulsions are infused at the same time, and the lipid peroxide caused by light cannot be completely eliminated. Preterm infants and newborns have limited peroxide storage and increase the risk of oxidative damage.
15. Vitamin K1
Vitamin K is a fat-soluble vitamin that easily decomposes when exposed to light and darkens.
16. Dacarbazine for Injection
Because this product is extremely unstable to light and heat, it can become red when it meets light or heat, and it is unstable in water. After the solution is placed, it becomes light red. Need for temporary preparation, immediately after dissolution. And try to avoid light.
17. Vincristine sulfate for injection
The drug is sensitive to light and should be protected from direct sunlight during administration.
18. Sodium p-amino salicylate for injection
The intravenous drip solution should be used immediately. The drip-proof solution should not be used in the dark. 8~12g of the drug is usually dissolved in 500mL of 5% glucose injection, and intravenous infusion is completed under dark conditions for 2 hours. However, in the course of instillation, the color of the infusion gradually deepened with the infusion time, and it could not be used for medicinal purposes. The color change of amino salicylate is mainly due to the decarboxylation reaction that produces brown m-aminophenol, which is then continuously oxidized to form diphenylhydrazine-type compounds.
Avoid light during intravenous drip to avoid drug decomposition.
20. Azasetron hydrochloride injection
This product is easy to decompose in case of light, should be used immediately after opening, and avoid light.
Slow light to avoid light infusion, unstable to light, prone to photolysis reaction, so that the antibacterial activity decreased. The photoexcited reaction is an exothermic reaction and is more likely to occur under solution conditions and aerobic conditions; photoreaction can not only produce degradants but also product polymerization.
22. Cefmetazole sodium
The agent will gradually change color when it encounters light, so it should be kept after opening.
When storing and instilling this medicine, it should be protected from light. It should be used immediately. The prepared liquid should be used within 8 hours.