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Clinically, if infertility patients are encountered, we should first check the cause of infertility.

In addition to screening for physical diseases and other factors, it is also necessary to screen whether there is any possibility of infertility due to taking drugs.

The adverse effects of the drug on the childbirth are medically known as drug-induced infertility. Improper use of drugs can induce infertility. Couples who are prepared to give birth should pay special attention to the problems of medication and infertility.

In addition to the famous anti-viral drug ribavirin, anti-acne drugs Victoria acid drugs, the following eight types of drugs should also try to avoid taking!

Sulfa drugs

Compound sulfamethoxazole: commonly used in the treatment of urinary tract infections, respiratory infections, tonsillitis and so on. Its side effects in reproduction are suppression of testicular function, reduced sperm count, and significantly reduced sperm mobility.

Sulfasalazine, a drug used to treat ulcerative colitis, can also cause semen deficiency, which can lead to 80% of sperm abnormalities, accompanied by a decrease in sperm count, sperm motility, and infertility.


Furlacillin and its derivatives: It inhibits carbohydrate metabolism and oxygen consumption in testicular cells, causing a decrease in the concentration of DHA in spermatogenic cells, resulting in decreased spermatozoa, leading to infertility.
Macrolide drugs, such as erythromycin, spiramycin, and medicamycin, can cause sperm development to stop and reduce mitosis.
It will hurt or kill the sperm, and the viable sperm motility is also significantly reduced.

Aminoglycosides can block the meiosis of the primary spermatocytes and therefore have a negative effect on spermatozoa.


Alias ​​cimetidine, this medicine is used to treat duodenal ulcer or upper gastrointestinal bleeding, a large number of continuous use can cause decreased sperm count and infertility. It has been reported that oral administration of 1200 mg daily can reduce sperm count by 43% after 9 weeks.


Excessive use of steroid hormones for a long period of time can inhibit the functions of the hypothalamus-pituitary-testicular axis in males, causing testicular atrophy and reduced sperm production, leading to infertility. This condition has been confirmed in male athletes who take steroid hormones for a long period of time.

The use of estrogen can cause impotence in men, delayed ejaculation, and inability to ejaculate. Even ejaculation has little semen volume.

The use of adrenocortical hormone can cause irregular menstruation and amenorrhea in women. Androgen can cause menstrual delay, hypersexuality and masculinity.

Sedative hypnotics

Long-term use or abuse of barbiturates and non-barbiturates sedative hypnotics can cause menstrual disorders and ovulation disorders in men, men may have decreased libido, impotence or loss of orgasm.

Chlorpromazine has effects on various segments of the nervous system. For example, it has increased prolactin in the hypothalamus and inhibited the secretion of gonadotropins, leading to decreased secretion of estrogen and testosterone. In men, impotence, difficulty in ejaculation, testicular atrophy, and men’s breast development may occur. Women may experience abnormal menstruation and amenorrhea.

Larger doses of clozazepam and safety can cause menstrual irregularities and irregular menstruation and ovulation disorders in women.

Antihypertensive drugs

Reserpine is a commonly used drug for the treatment of hypertension. It can deplete tissue catecholamines and produce a significant sedative effect, thereby indirectly reducing libido. The long-term use of antihypertensive drugs affects the hypothalamus pituitary function, thereby inhibiting the production of sperm, reducing spermatozoa and even sperm, leading to infertility.

Step-down spirit, propranolol, methyldopa, etc. can cause decreased sexual desire, irregular menstruation and no ejaculation.

Anti-tumor drugs

Cyclophosphamide is a commonly used anti-cancer drug for the treatment of multiple myeloma and various cancers, but also for the treatment of nephritis, etc., generally adult dosage 0.1-0.2 grams per day. When the total daily amount reaches 6-10 grams, it will cause a significant reduction in the number of sperm, even without sperm, and women may experience menstrual cycle disorders. Cyclophosphamide-induced infertility is related to the amount of medication used, and the greater the dose, the less likely it is to restore fertility. When men enter puberty, they are very sensitive to this drug.

Chlorambucil has toxic side effects on the gonads, and 80% of puberty patients suffer from azoospermia after medication. If the patient’s total medication exceeds 25 mg/kg body weight, irreversible oligozoospermia or azoospermia will occur.

Anesthesia and analgesics

Morphine, pethidine, heroin, etc. can interfere with the regulation of the hypothalamic pituitary system, so that the penis can not erect or erection is not strong enough to complete the sexual intercourse process, resulting in ejaculation disorders, leading to infertility.

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