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We often heard that “drink plenty of water” while taking medicine. Do you take any medicine and drink the same amount of water? When the pills are swallowed, what’s the matter?
Actually, the requirements of drugs for water are not generalized. Most commonly used drugs require a mouthful of water to moisturize the throat and esophagus to prevent the tablets from sticking to the side walls and drink the right amount of water when taking the drug. However, different drugs have different properties. The mechanism of effect is different, and the amount of drinking water is also different. Which drugs should be used for drinking more water? Which drugs should drink less water?

I. Drink more water after taking medicine

1) Quinolone drugs

Such as ciprofloxacin, levofloxacin, etc. These kind of medications are mainly excreted by the kidneys. High doses of fluoroquinolones or urine pH value of 7 or more can lead to crystalline urine, in order to avoid the occurrence of that, patient should drink more water to maintain 24-hour urine output above 1200ml.

2) Sulfa drugs

Such as compound sulfamethoxazole, etc. Also, due to sulfa drugs mainly excreted by the kidneys, it is easy to form crystallization in urinary tract and cause stimulation and obstruction. Drinking plenty of water can wash away the urine crystals, can also add sodium bicarbonate to alkalinize the urine, to promote the dissolution of crystals and reduce the crystallization of the urethra damage.

3) Aminoglycosides

Gentamicin, amikacin and other aminoglycoside antibiotics have kidney toxicity, the higher concentrations the greater damage to the renal tubules, plenty of water should be drunk to dilute and accelerate drug excretion.

4) Antiviral drugs

Acyclovir, famciclovir, etc. can lead to crystalline renal failure, so during the medication people should drink more water.

5) Anti-tumor drugs

Metabolism of methotrexate, cyclophosphamide, etc. in the human body is mainly excreted by the kidneys through the prototype. If the intake of water is insufficient, excessive concentration of the drug in the urine may cause crystal formation to cause hemorrhagic cystitis and acute kidney damage.

6) Antiasthmatic drugs

Such as aminophylline, doxofylline, etc. These drugs have diuretic effect, so it is easy to be dehydration. Meanwhile asthma is often associated with lower blood volume. Therefore, appropriate body fluids should be added, drink plenty of boiled water would help.

7) Gallbladder medicine

Such as gall capsule and ursodeoxycholic acid. Some bile drugs can cause excessive bile secretion and diarrhea, so patients should drink as much water as possible to avoid diarrhea and dehydration.

8) Some proprietary Chinese medicines

For example, people should drink plenty of water when taking Jintiange capsules for healthy bones.

9) Anti-calculus drugs

Such as proprietary Chinese medicine, Paishi Decoction, Wu Lin fossil pills, etc. After taking those, one should drink plenty of water to rinse the urethra, dilute the urine, reduce the concentration of urinary salts, and reduce the chance of urinary salt precipitation.

10) Bisphosphonates

Such as sodium alendronate, clodronate disodium, etc. Bisphosphonates, in the treatment of hypercalcemia, can cause electrolyte imbalance and water loss. It should pay attention to add body fluids, so that the daily urine output should be 2000ml or more. At the same time, bisphosphonates are irritating esophagus, therefore they should be delivered with 200 ml of water. For the same reason, patient should not be supine immediately after taking the medicine and should keep the upper body upright for at least 30 minutes.

11) Anti-gout drugs

Such as other sterols, benzbromarone, etc. The application of uric acid drugs for the treatment of gout should be taken with plenty of water. Make sure that the amount of drinking water is not less than 2L, while the alkalinization of urine to prevent the formation of uric acid in the urinary tract during the discharge of stones.

12) Electrolyte

Such as oral rehydration salts (ORS), etc. Drink plenty of water, add 500-1000ml water to dissolve the salts in each bag. Oral rehydration salts II are a bit high due to osmotic pressure, and the amount of dilution water given to children should be 1.5 times of that on the instructions.

13) Antipyretic Analgesics

When taking antipyretic analgesics, a cold patient may have a large amount of drinking water. On the one hand, it helps the body to urinate to metabolize toxins in the body. At the same time, the antipyretic drugs cause the patient to sweat a lot, and drinking water can regulate the balance of water and electrolyte in the body.

14) Drugs that are prone to dry mouth

Such as atropine, anisodamine and so on.

II. Drink less water after taking medicine

1) Gastric mucosal protective drugs

Such as Smecta, Shi Lin particles, sucralfate, Daxi, etc. Patient only needs a small amount of water delivery service. And within half an hour after taking the drug patient should not drink water, so that the drug in the damaged gastric mucosa to form a protective film.

2) Antitussive

Various cough syrup, such as compound licorice mixture, mainly through the covering of the respiratory mucosa, the formation of a protective film, reducing nerve endings stimulation, to achieve cough effect. Do not drink water immediately after taking the medicine to facilitate the formation of the protective film. If you feel dry mouth, you should drink water after taking the medicine for half an hour.

3) Bitter and stomachic

The compound gentian is to use its bitter taste, through the tongue’s taste receptor, reflexively promote the secretion of gastric juice to increase appetite, so it should not be taken with plenty of water, which would dilute the bitter taste and affect the efficacy.

4) Lozenge

Because drinking too much water can weaken its throat and and mucosal protection.

5) Cardiovascular drugs

Such as nitroglycerin tablets, Musk Baoxin pills and other sublingual, which are absorbed by the sublingual vein to achieve quick effect, without water delivery service.

6) Antidiuretic drugs

Drinking water should be restricted during taking this type of medication, such as vasopressin, desmopressin. Otherwise, it may cause water retention or hyponatremia symptoms and complications.

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