Metformin was introduced in 1957 and has been used clinically for more than 50 years. It is currently one of the most widely used oral hypoglycemic agents in the world. Metformin has good evidence of efficacy and safety of single-agent/combination therapy, as well as evidence of good health economics. Regardless of blood sugar control, or the prevention of cardiovascular cardiovascular complications, it has clear clinical evidence. Therefore, the drug has become the world’s leading drug for the control of diabetes. Its mechanism of action is to reduce the production and output of hepatic glycogen and lower the blood glucose level, and to increase the utilization of glucose in peripheral tissues such as liver, fat, and muscle tissue cells, and to promote the anaerobic glycolysis of sugar.
A study found that metformin monotherapy in newly diagnosed diabetic patients for 16 weeks reduced the body weight of normal, overweight, and obese patients by 1.47, 2.81, and 2.92 kg, respectively. Patients taking metformin to control blood sugar can also lose weight. This is an additional benefit for obese diabetics. Therefore, metformin is clinically used to treat obese type 2 diabetes. At the same time, some people with weight loss needs to start taking metformin to lose weight.
So, is it effective to use metformin for weight loss in healthy, obese adults?
Studies have shown that in obese people, the main cause of simple obesity is the accumulation of adipose tissue in the body and the formation of a disproportionate proportion of fat and muscle tissue. The best weight loss measures are mainly to reduce fat tissue and increase the proportion of muscle tissue in order to achieve the effect of bodybuilding. Metformin does not reduce the accumulation of adipose tissue in the body. It merely increases glucose and anaerobic metabolism in muscle and reduces the energy supply of glucose to muscle tissue. Therefore, although the weight decreased after taking metformin, but the users will feel muscle weakness, fatigue, etc., can not achieve the purpose of real fitness.
Moreover, taking metformin to lose weight must reach a dose of more than 1,000 milligrams per day to lose weight. This dose is greater than the usual dose (750 milligrams per day) for the treatment of diabetes, and there is a corresponding increase in side effects.
According to statistics, 15%-28% of patients with higher doses of metformin have obvious gastrointestinal reactions, mainly manifested as diarrhea, nausea, vomiting, abdominal distension, oral odor, etc., of which diarrhea is heavier. %about. Metformin 1000 mg daily is also easy to cause lactic acid accumulation, lactic acidosis can occur, symptoms such as confusion, lethargy appear.
In addition, long-term high doses of metformin will affect the absorption of vitamin B12, leading to megaloblastic anemia. It can be seen that metformin is only a hypoglycemic agent for obese diabetic patients, but not a safe weight loss drug. Remind those “beautiful people” to lose weight or rely on a reasonable diet, exercise, and fat consumption to achieve the goal. In this way, you will not only have a perfect figure, but also have a healthy body!